Al And N Express Your Answer As A Chemical Formula Bee Propolis: Synergisitc Health Care for the 21st Centruy

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Bee Propolis: Synergisitc Health Care for the 21st Centruy

Modern science has progressed at an amazing rate for over a century. This increase in knowledge has been accompanied by medical and health services that have reached a peak and diseases have been eradicated. These medical advances were based on the “magic bullet” paradigm of isolating an active ingredient and using it to alter the chemistry of a single molecule/protein to induce a change in a patient’s condition. However, success has become an obsession as cracks appear in the arsenal of disease-fighting drugs at our disposal. MRSA is spreading in our hospitals because antibiotics are becoming ineffective and serious side effects from modern drugs have become common years after they were introduced. As a direct consequence of the one-dimensional strategy, perhaps it is time to recognize the synergistic health benefits of natural medicine.

Propolis is a unique natural medicine due to its scope of action. It has antibacterial, antiviral, antifungal, anti-inflammatory, anti-cancer and immunomodulatory effects and can help treat asthma, allergies, arthritis and joint disease, eczema and dermatitis, ME, viral infections including HIV and even cancer. This medicine can help treat diseases or keep you fit and healthy.

Propolis: Defender of the city

Propolis is primarily a resinous substance collected by bees from trees and plants. Consists of waxes, resins, fatty acids and even amino acids. Aristotle is said to have coined the name Propolis, which means “protector of the city.” This is exactly what propolis is for the hive, it acts as the bee population’s external immune system, keeping the hive sterile and free of microbial invaders.

Evidence-based medicine

In the following paragraphs, I will describe to you the pharmacological properties of propolis. Before that, I need to explain where this evidence comes from. All the properties and actions of Propolis have been recognized and discussed in detail in scientific studies that have subsequently been published in journals. The majority of these scientific studies are done in vitro (ie in a test tube) or in vivo (ie in host animals such as rats), a much smaller proportion of these studies are clinical trials that are tested in humans. Abstracts of these papers can be found in Medline and published databases on the Internet.

Propolis: a natural antibiotic

Propolis is probably best known for its antibiotic properties. Already in 1960, French1 studies showed a bacteriostatic effect against Bacillus subtilis, Proteus vulgaris and Bacillus alvei. The results have been replicated many times and propolis has even been shown to be effective against MRSA2, the same antibiotic-resistant bacteria that has infected up to 70% of our hospitals. A 1997 study by Calder et al. The University of Oxford agreed with these results and found that especially the cinnamic acids and flavonoids in propolis have a bactericidal effect. This action is thought to be due to propolis breaking down the bacterial energy respiratory chain. Interestingly, when used together, this effect may be related to a synergistic effect with antibiotics, which increases the effectiveness of the drugs.

Antiviral and immunostimulating

Viruses present a unique dilemma in the pursuit of good health, being unaffected by antibiotics and mutating so frequently that vaccines are difficult to produce. They also cause disease by hijacking cells and using cellular machinery to reproduce. Modern drugs aim to slow down or stop the virus from multiplying, and therefore, because they attack the host cell’s machinery, they have certain side effects. Viruses pose perhaps the greatest threat to human health, and we are currently in the midst of an HIV pandemic, with 39.4 million people worldwide infected. With a flu pandemic overdue and sure to emerge, and predictions of global casualties and chaos, a solution is needed.

Bioflavonoids in propolis have a unique approach to fighting viruses, instead of trying to fight them once they have infected a cell, they lock the virus inside its protein coat. This means that the virus’s dangerous mechanism and DNA/RNA are reset and the infection stops.

In a clinical trial conducted in Ukraine4, propolis has been shown to be more effective than the pharmaceutical antiviral acyclovir in the treatment of genital herpes, and there is growing evidence that propolis can help treat people with HIV infection5.

Propolis also works hard as an immunomodulator, which is of interest to all of us. It does this by altering the control of cytokine production and release. Cytokines are chemical messengers that allow immune system cells to communicate. By altering the cytokine system, it primes the immune system to be ready to respond quickly and effectively to antigens.

In addition, bioflavonoids in propolis stimulate the production of interferon, which can help people recover from IUD by stimulating their immune system. This change in the cytokine and interferon systems means your body is ready to fight infections and keep you healthy, which is why using propolis as a health supplement like vitamins is good. Prevention is better than cure.

Anti-inflammatory and anti-allergic

A survey of propolis consumers showed that arthritis was the health problem for which propolis was most commonly used. This is due to the potent anti-inflammatory properties of propolis constituents, particularly CAPE (Caffeic Acid Phenyl Ester), CAPE has been shown to inhibit T-cell activation. A 2004 article by Marquez et al.6 assessed that since T cells play a key role in the development of several inflammatory diseases, CAPE is important because this phenolic compound is a potent inhibitor of early and late T cell events. receptor-mediated T cell activation. Such results have led other researchers to suggest that CAPE is a useful tool for reducing the severity of inflammation-related conditions.

Many experiments with CAPE were performed in vitro, but the anti-inflammatory properties of propolis have been documented in rats when treated with rat adjuvant arthritis. A 1999 paper by Park et al concluded that an ethanol extract of propolis has profound anti-inflammatory effects on both chronic and acute arthritis. These anti-inflammatory properties extend to other diseases and disorders such as asthma and allergies, reducing both airway smooth muscle contractions8 and allergic reactions. Propolis can help with any inflammation-related disorder or disease.

Anti-tumor/anti-cancer

Propolis and CAPE have been shown to reduce the size of tumors and kill and inhibit the growth of malignant cells in many different types of cancer. As recently as June 10, 2005, a million dollar grant was awarded to cancer researchers to study the therapeutic value of propolis against cancer. Costas Koumenis, lead researcher of the study, said: “A very interesting property of these compounds is that they have been shown to induce cell death in tumor cells but not in normal cells.” This study, along with other current research, promises to push propolis into the limelight in the field of cancer treatment.

Current propolis research in the UK

BVR (BeeVital Research) recently won a major government R&D award as part of a £250,000 research program into the chemical, biological and clinical properties of propolis.

These studies focus on the following topics:

1. Documenting regional differences in chemical and biological properties using HPLS, GC-MS and NMR. (Held at University of Strathclyde)

2. Further investigation of the role of propolis in the hive (University of Gloucester)

3. Dental research – studying the effectiveness of propolis in mouth ulcers, pericorinitis, gingivitis and sensitive teeth. (University of Manchester School of Dentistry)

4. HIV/AIDS research – studying the effectiveness of propolis and antiviral drugs in Zambia and Tanzania

5. Effects of Standardized Propolis on Mood, Stress, Fatigue and Cognition at Newcastle University Human Cognitive Neuroscience.

6. To evaluate the use of local and non-local propolis in wound healing and in the treatment of skin and other dermatological problems. (University of Dar es Salaam Regional Teaching Hospital)

How to use/find propolis products?

A wide range of propolis products are available on the market, from tablets, capsules, tinctures and liquids to specialized skin care products – soap, lip balm, creams and oral care products – toothpaste, mouthwash, pastilles and dentifrices.

They have traditionally been available in health food stores, but are increasingly available in independent pharmacies.

Choosing the best product is not always easy. Current regulations mean that manufacturers cannot make any medical claims about products that are not licensed as medicines, despite the fact that there is a solid basis for such claims. Part of the reason for this is that no agency is responsible for ensuring that the product they are offering for sale is actually what they say it is.

For this reason, the BVR (BeeVital Research) program is aimed at developing full drug licenses for certain key products. Meanwhile, BVR has developed several products for the health food market based on its research. When purchasing products, consumers should look for products manufactured by companies that can support their products with good manufacturing practice (standard pharmaceutical manufacturing) and scientific research.

References:

(1) Lavie, P. (1960). Annals Abeille, 3: 103-201

(2) Antibacterial properties of propolis. Grange, JM, Davey, RW Journal of the Royal Society of Medicine, 83: 160-1 (1990)

(3) Antimicrobial activity of propolis and some of its components: effects on growth membrane potential and bacterial motility. Mirzoeva, OK, Grishanin, rn, Calder, pc microbial – res, 152: 239-246 (1997)

(4) A comparative multicenter study of the efficacy of propolis, acyclovir, and placebo in the treatment of genital herpes (HSV). Vynograd, N.; Vynograd, I.; Sosnowski, Z. Institute of Epidemiology, Lviv State Medical University, Lviv, Ukraine. Phytomedicine (2000), 7 (1), 1-6. CODE: PYTOEY ISSN: 0944-7113.

(5) Current lead natural products for chemotherapy of human immunodeficiency virus (HIV) infection. De Clercq, Erik. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Louvain, Belg. Medicinal Research Reviews (2000), 20(5), 323-349. CODE: MRREDD ISSN: 0198-6325

(6) Caffeic acid phenethyl ester inhibits T cell activation by targeting both nuclear factor of activated T cells and NF-B transcription factors. Marquez, Nieves; Sancho, Rocio; Macho, Antonio; Calzado, Marco A.; Fiebich, Bernd L.; Munoz, Eduardo. Departamento de Biologia Celular, Fisiologia e Inmunologia, Universidad de Cordoba, Facultad de Medicina, Cordoba, Spain. Journal of Pharmacology and Experimental Therapeutics (2004), 308(3), 993-1001. CODE: JPETAB ISSN: 0022-3565.

(7) Inhibitory effect of propolis on rat adjuvant arthritis. Park, Eun-Hee; Kahng, Ja-Hoon. College of Pharmacy, Sookmyung Women’s University, Seoul, South Korea. Archives of Pharmaceutical Research (1999), 22(6), 554-558. CODE: APHRDQ ISSN: 0253-6269.

(8) Bulgarian propolis induces analgesic and anti-inflammatory effects in mice and inhibits airway smooth muscle contraction in vitro. Paulino, Niraldo; Dantas, Andreia Pires; Bankova, Vasya; Longhi, Daniela Taggliari; Scremin, Amarilis; Lisboa de Castro, Solange; Calixto, Joao Batista. Grupo de Pesquisa y Desenvolvimento de Biofarmacos (BIOFAR), Universidade do Sul de Santa Catarina, Tubarao, Brazil. Journal of Pharmacological Sciences (Tokyo, Japan) (2003), 93(3), 307-313. CODE: JPSTGJ ISSN: 1347-8613.

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