What Is The Difference Between Formula Mass And Molecular Mass L-Glutamine – The Miracle Amino Acid and How You Can Benefit From Its Use

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L-Glutamine – The Miracle Amino Acid and How You Can Benefit From Its Use

I don’t believe in miracles – I depend on them. – Raymond Dale

I am completely mystified… For some strange reason glutamine or L-Glutamine as it is officially christened has not yet been discovered by the world at large as of today! What do I mean by discovered? Well, it just seems a little odd to me that an amino acid that makes up most of your skeletal muscle mass and is depleted by daily and excessive exercise doesn’t play a bigger role in muscle repair, recovery, and general maintenance…more than 60% of your body. Glutamine is an amino acid found in the proteins of all life forms and is classified as a semi-essential or conditionally essential amino acid. This means that under normal conditions the body can synthesize enough L-glutamine to meet physiological needs. However, there are situations where the body cannot do this. So my dilemma is, should I open the floodgates and proclaim to the world how important glutamine is, or should I contribute to suppressing it, which I believe is one of the elements necessary for body integrity and overall health? You know what… I do what I do and that means the truth, and I’ll let you determine how important glutamine is for you. Okay? Excellent!

Recently, glutamine has gained a reputation as simply an important amino acid when the body is subjected to metabolic stress situations such as trauma (including surgical trauma), cancer, sepsis, and burns. This list also includes trauma or overuse. The core training of athletics, the emotional stress and the daily rigors of a demanding lifestyle, I couldn’t agree more. Under these conditions, L-glutamine becomes an essential amino acid, and it is therefore very important to ensure adequate intake or replacement of the amino acid to meet the increased physiological and psychological demands resulting from these circumstances. But again, with all the physiological, psychological and dare we say mental stressors we are subject to…my personal assessment (guess) is that glutamine is far more important to us than those in positions of power, persuasion and influence would have us believe put. Logic says that if we break down faster, more often, and do it often… well, there’s just a system that takes care of us… think about it!

Fortunately, glutamine is indeed and by far the most abundant amino acid found in the body (thank goodness for science), and plasma (blood) glutamine levels are the highest of any amino acid. Glutamine is produced (synthesized) and stored mainly in skeletal muscles. The amino acid L-glutamate is metabolized to L-glutamine in a reaction catalyzed (to initiate the chemical reaction and its progress under different conditions) by the enzyme glutamine synthase, which requires ammonia in addition to L-glutamate. , ATP and magnesium… dig?

And if that’s not exciting enough, glutamine is also an openly multi-purpose amino acid and is involved in many reactions in the body. Glutamine is very important in regulating the acid-base balance, and in addition, glutamine allows the kidneys to excrete the acid load, protecting the body from acidosis. This is achieved by the production of ammonia, which binds hydrogen ions to produce ammonium cations (a positively charged polyatomic ion with the chemical formula NH4+ and a molecular weight of 18.04 resulting from the protonation of ammonia (NH3)), which are excreted in the urine along with chloride anions. At the same time, bicarbonate ions are released into the bloodstream. If that’s just not powerful enough, check this out…glutamine helps protect the body from ammonia toxicity by transporting ammonia in the form of the glutamine amide group from peripheral tissues to visceral organs where it can be excreted as ammonium. kidneys or converted to urea in the liver. Sorry for the science ramble, but since I feel wholeheartedly that glutamine is so important, I only think it’s only right to get these messages across, so without further ado…some more…mumbo-jumbo (nonsense).

This wonderful amino acid is also involved in other metabolic activities such as; acts as the most important nitrogen shuttle, supplying nitrogen for metabolic purposes (from glutamine-producing tissues such as skeletal muscle) to glutamine-consuming tissues. Pretty cool right? Well, that’s not all bullshit, please continue.

In addition to all this good, glutamine also participates in the formation of purine and pyrimidine nucleotides, amino sugars (eg glucosamine), L-glutamate and other amino acids, nicotinamide adenine dinucleotide and glutathione. Also participating in protein synthesis, energy production and, if necessary, also in the production of D-glucose and glycogen. Importantly, glutamine can act as the primary respiratory substrate (a material or substance on which an enzyme acts, or a surface on which an organism grows or attaches) for energy production in enterocytes and lymphocytes. Glutamine is considered an immune nutrient, and supplemental L-glutamine is used in medical foods for stressful situations such as the aforementioned traumas, cancers, infections and burns, and post-burn infections of any degree.

The potential immunomodulatory role of supplemental glutamine can be accounted for in several ways. Glutamine appears to play an important role in protecting the integrity of the gastrointestinal tract, and especially the large intestine. During catabolic states, the integrity of the intestinal mucosa may be compromised, resulting in increased intestinal permeability and translocation of gram-negative bacteria from the large intestine into the body. The glutamine requirement of the gut and also of cells such as lymphocytes appears to be much greater than that of skeletal muscle, the primary tissue for glutamine and glutamine storage being the preferred respiratory fuel of enterocytes, colonocytes and lymphocytes. Therefore, under these conditions, supplying additional glutamine can do a number of things. First, it more than likely reverses the catabolic state, sparing skeletal muscle glutamine. It can also inhibit the translocation of gram-negative bacteria from the large intestine. Glutamine helps maintain secretory IgA, which functions primarily by preventing bacteria from attaching to mucosal cells.

Digestive tract performance.

There is now a significant body of evidence linking glutamine-enriched diets to positive effects on the gut; aiding and maintaining intestinal barrier function, intestinal cell proliferation, as well as aiding in overall reduction of septic morbidity. The reason for such cleansing properties is believed to be due to the fact that the rate of extraction of glutamine from the intestine is higher than that of other amino acids, and it is the most viable option in the future for the relief of conditions related to the intestine. These conditions were discovered after comparing gastric plasma concentrations between glutamine-enriched and non-glutamine-enriched diets. Although glutamine is believed to have cleansing properties and effects, the extent to which it has clinical benefit is unknown because glutamine concentrations vary in different foods.

In addition, glutamine appears to be required to support mitogen-stimulated lymphocyte proliferation as well as interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production. It is also required for the maintenance of lymphokine-activated killer cells (LAK). Glutamine can increase the phagocytosis of neutrophils and monocytes. This may lead to an increase in glutathione synthesis in the gut, which may also play a role in maintaining the integrity of the intestinal mucosa by alleviating oxidative stress.

But on the other hand, the exact mechanism of possible immunomodulatory effect of supplemental glutamine is still unresolved. It is my opinion, and it is more than conceivable, that the main effect of glutamine is manifested at the level of the intestine (stomach). It is possible that enteral glutamine clearly acts on gut-associated lymphoid tissue and stimulates general immune function through this mechanism, without bypassing the splanchnic bed.

Glutamine reduces post-burn infections

According to a fairly recent study in Critical Care Medicine (2003; 31:2444-9), glutamine reduces the risk of infection and may lead to fewer deaths and shorter hospital stays in burn victims. In the study, 41 adults under the age of 65 with severe burns covering 20 to 80% of the skin were given a standard diet via feeding tube supplemented with 4.3 grams of glutamine or other amino acids (aspartic acid, asparagine, and glycine) every four hours (up to 26 grams per day). Treatment was continued until the burns were completely healed. Hospital length of stay, incidence of bloodstream infections and number of deaths were recorded.

The incidence of blood infections was three times higher in those who received the control formula than in those who received supplemental glutamine in their feeding tubes. There were no deaths among the 19 people who survived the first 72 hours in the glutamine group, compared with eight deaths among the 16 people who survived the first 72 hours in the control group. The time spent in the hospital was also significantly shorter in those receiving glutamine.

The anti-catabolic/anabolic activity of supplemental glutamine can be explained by its effect and efficiency in sparing skeletal muscle glutamine stores.

Glutamine powder is a tasteless, easily mixed, pure, free amino acid powder.

What it can do for you…

Clinical studies show that glutamine supplementation can aid in recovery after intense exercise by promoting the restoration of energy stores, maintaining a healthy immune system, and maximizing your body’s buffering capacity against lactic acid build-up.

Again, glutamine is the most common amino acid found in your muscles – over 6o% ​​of skeletal muscle is indeed glutamine. It is made up of 19% nitrogen, making it the primary transporter of nitrogen into your muscle cells. During extreme exercise, glutamine levels in your body are greatly reduced, which reduces strength, endurance, and recovery. It may take up to a week for glutamine levels to return to normal. Glutamine supplementation can minimize muscle breakdown and improve protein metabolism.

In addition to playing a key role in protein metabolism, cell bulking, and anticatabolism, glutamine also increases your ability to secrete human growth hormone, which helps metabolize body fat and supports the growth of new muscle tissue. Glutamine’s anti-catabolism ability prevents the breakdown of your muscle integrity. This is especially useful for those who “cut” you. Especially from spring to summer when you’re trying to shed unwanted body fat without losing any of your hard-earned muscle.

Primarily because glutamine levels are depleted during exercise, bodybuilders are more susceptible to disease and this is why glutamine supplementation is so important, not necessarily for building muscle, but for maintaining muscle integrity and physical vitality, and because glutamine supplementation promotes positive nitrogen balance and prevents muscle loss. Recent studies have also shown that taking just 2 grams of glutamine can increase growth hormone levels by as much as 400%.

If all of this isn’t enough proof for you to do a little research on your own, I just don’t know what to tell you, but if I’ve contributed to your interest in glutamine, I’ve done what I set out to do…and that’s the TRUTH passing on! Here’s to you, your life force and truth. -Know yourself!

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